Endocrine Abstracts

Background: Diabetes Mellitus (DM) is an endocrine disorder resulting in hyperglycaemia that affects many vital organs of the body like the brain. The molecular mechanisms underlying dementia, memory loss and cognition dysfunction caused by DM are still not very clear. CD47 is a cell surface protein working in the homeostasis of the immune system. The causal relationship of CD47 has been shown in neurodegenerative diseases. CD47 also has a role in pancreatic islet cells and th...

Objective: It has been argued that salivary alpha-amylase (sAA) is a potential indirect sympathoadrenal medullary (SAM) system activity marker. This study aimed to look at sAA to assess the sympathetic nervous system in acromegaly patients.Subjects and Methods: A total of 31 individuals with acromegaly and 30 controls were enrolled in this prospective, single-center investigation. Saliva samples were taken from individuals with acromegaly and controls in...

Aim: Serum sclerostin levels as an indicator of bone resorption in children with congenital adrenal hyperplasia (CAH) have not been evaluated to date. The aim of this study was to determine the role of osteoprotegerin (OPG) and sclerostin in bone metabolism in children with CAH.Methods: Thirty-one patients (19 girls, 12 boys) with CAH (aged 11.6±3.7 years) and 31 healthy children (age- and sex-matched) as controls were included in the study. The patie...

Introduction: Hypophysitis is a rare pituitary inflammation due to primary and secondary causes. Xanthomatous hypophysitis is the rarest subtype and described with lipid-laden cystic areas, transparent cytoplasmic and lipid-laden histiocytes and foamy (xanthomatous) histiocytes. Although the etiology of xanthomatous hypophysitis is not clearly known, it has been suggested to develop as a result of autoimmune cause or inflammatory process of infiltration of cyst components from...

Aim: Traumatic brain injury (TBI) is known to be associated with pituitary insufficiency (PI). We have recently shown that there was a relationship between miR-126-3p, miR-3610 and PI developing in follow up of patients with TBI. In this study, we aimed to test the effects of miR-126-3p on hypothalamus pituitary-adrenal (HPA) and Growth hormone-Insulin like growth factor (GH-IGF-1) axes.Materials and methods: miR126-3p microinjection was performed to mou...

Aim: The etiology and underlying pathology of non-functional adrenal adenoma has not been clearly defined, yet. Blood pressure levels according to adrenal adenoma size has not been evaluated, yet. Therefore, we evaluated 24 hour ambulatory blood pressure levels in patients with non functional adrenal adenoma.Materials & Methods: We studied thirty newly diagnosed adrenal adenoma patients in a tertiary health-care center. They grouped in two categories...

Introduction: Vitamin D is a fat soluble prohormone and can be produced in the body with adequate sunlight exposure or taken up by consumed foods or supplements. Recently vitamin D deficiency has been seen in pandemic. A rare disease, vitamin D intoxication is usually iatrogenic. High levels of 25(OH) vitamin D increases the intestinal calcium absorption and causes severe and refractory hypercalcemia. In this case report we presented a patient with pancreatitis and hypercalcem...

Background and aim: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorder in women with reproductive age. Nodular goiter and autoimmune thyroid disease (AITD) are frequently seen endocrinological abnormalities. The aim of this study was to identify the prevalence of AITD and nodular goiter in PCOS patients and investigate whether PCOS related hormones and metabolic factors affect these thyroid disorders.Methods: Ninety-seven with ...

Purpose: The purpose of this study was to evaluate the relation polycystic ovarian syndome (PCOS) and the thiol/disulfide balance, used as a marker of oxidative stress, by measuring that exchange using a novel technique.Material/methods: Fourty nine subjects diagnosed with PCOS and 44 healthy were included in the study. Thiol/disulfide homeostasis concentrations were measured by a newly developed method. After native thiol, total thiol and disulfide leve...

Introduction: Certain sensory system functions are affected somehow in acromegaly, however auditory complications have not been identified in detail yet. It is possible that widespread changes in acromegaly may also affect auditory system. We aimed to determine the changes involving auditory system in cases with acromegaly.Methods/design: Otological examination of 41 cases with acromegaly (active n=22, inactive n=19) were compared with ...